Studies on the Synthesis of Hippuric Acid Derivatives. I

Studies of Liver Function. Benzoate Administration and Hippuric Acid Synthesis

Much work has been done in an effort to understand the complex function of the liver and considerable information of value has been obtained. It is fair to say, however, that the estimation of functional capacity of the liver cannot as yet be made with any convincing accuracy. We have reason to believe that the liver has a very large factor of safety-that it can tolerate an extensive injury and...

Studies on the Synthesis of Hippuric Acid in the Animal Organism

The source of the glycocoll made available for detoxication after the ingestion of benzoic acid or its salts is not known. The possibility that hippuric acid is formed from the glycocoll secreted as glycocholic acid in the bile either in the intestine or in the circulatory system has been suggested. Such a theory would ascribe to the bile an important function. Little experimental evidence in s...

Studies in the Synthesis of Hippuric Acid in the Animal Organism. Ii. the Synthesis and Rate of Elimination of Hippuric Acid after Benzoate

The question of the extent of the ability of the human organism to detoxicate benzoic acid by conjugation with glycocoll and elimination as hippuric acid in the urine has frequently been raised. Lewinsk? observed in the urine of men to whom 12 to 20 grams of benzoic acid had been given in small doses during t,he course of twelve hours, neither free benzoic acid nor benzoyl glycuronates. With la...

The Role of the Liver in Hippuric Acid Synthesis.

histological evaluation of the effect of three medicaments; trichloracetic acid, formocresol and mineral trioxide aggregate on pulpotomized teeth of dogs

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