Studies on the Syntheses of Condensed Indole-4, 7-dione Derivatives. III. Syntheses of Pyrrole-2-acetic Acid Derivatives using γ-Amino-n-butyric Acid and γ-Amino-β-hydroxy-n-butyric Acid as a Synthon of Pyrrole
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Gamma-hydroxybutyrate / Butyric Acid
Gamma-hydroxybutyrate / butyric acid, ambiguously called GHB, presents some unique challenges for analysis due in part to its acidity, high polarity, and high solubility in aqueous solution. Its chemistry is complicated by its conversion into the corresponding lactone compound, where the GHB molecule condenses to form a cyclic ester with a five-membered ring. This compound, gamma-butyrolactone ...
متن کاملModification of tritiated gamma-amino-n-butyric acid transport in rabies virus-infected primary cortical cultures.
The role of brain neurotransmitter transport processes in rabies virus infection of neurons was examined. The uptake and release of gamma-amino-n-butyric acid (GABA) in rabies virus-infected embryonic rat cortical neurons was assayed using tritiated ligands. A 45% reduction of [3H]GABA uptake was observed 3 days post-infection, when a maximum level of infectious particle release occurs. At this...
متن کاملTHE SPATIAL CONFIGURATION OF a-AMINO-p- HYDROXY -n-BUTYRIC ACID *
Several months ago McCoy, Meyer, and Rose (1935) described the isolation and identification of cr-amino+-hydroxy-n-butyric acid as a cleavage product of proteins, and demonstrated that the new amino acid is an indispensable component of the diet. Since that time attention has been directed to the determination of the spatial configuration of the compound. It is the purpose of the present paper ...
متن کاملeffects of aqueous extract of saffron on gamma-amino butyric acid content in rat hypothalami
background preliminary studies revealed that 4-aminobutyric acid (gaba) is a key and major inhibitory neurotransmitter in the brain. evidence from many animal studies and even some clinical studies indicate that gaba is responsible for regulating behavior and also plays an important role in brain functions. previous studies presented glutamic acid decarboxylase as a catalyst for the conversion ...
متن کاملProduction of GABA (gamma amino butyric acid) by Lactic Acid Bacteria
Gamma-amino butyric acid (GABA) is a kind of pharmacological and biological component and its application is wide and useful in Korea specially, becoming aging society in the near feature. GABA is request special dose for the purposed biological effect but the production of concentrated GABA is very difficult due to low concentration of glutamic acid existed in the fermentation broth. To increa...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1982
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.102.8_748