Studies on Synthetic Sweetening Agents. XIV. Metabolism of Sodium Cyclamate. (3). On Metabolites of Sodium Cyclamate in Human
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چکیده
منابع مشابه
Feeding studies on sodium cyclamate, saccharin and sucrose for carcinogenic and tumour-promoting activity.
Groups of 50 female Swiss mice were fed for 18 months on a standard diet containing sucrose (10 %), sodium cyclamate (5 %) or saccharin (5 %), while 100 control mice were fed on the standard diet alone. The survival times were comparable in all groups and no acute toxic effects were encountered. No local tumours in the gastro-intestinal tract, nor excess incidence of distant tumours, were found...
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Since cyclamates were first introduced in the early 1950s, arguments have raged over the potential carcinogenicity of this artificial sweetener. Concern over the safety of cyclamates arises from observations that some individuals and experimental animals can metabolize cyclamate to cyclohexylamine and that cyclohexylamine has been shown to produce testicular atrophy in experimental animals. Thi...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1969
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.17.2620