منابع مشابه
An unexpected copper(II)-catalyzed three-component reaction of quinazoline 3-oxide, alkylidenecyclopropane, and water.
An unexpected copper(II)-catalyzed three-component reaction of quinazoline-3-oxide, alkylidenecyclopropane and water under mild conditions is reported. This transformation including [3+2] cycloaddition and intramolecular rearrangement leads to N-(2-(5-oxa-6-azaspiro[2.4]hept-6-en-7-yl)phenyl)formamides in good yields.
متن کاملN 4-(3-Bromophenyl)quinazoline-4,6-diamine
In the title compound, C(14)H(11)BrN(4), the fused benzene and pyrimidine rings are nearly coplanar, making dihedral angles of 1.26 (14) and 3.53 (15)° in the two independent mol-ecules. In the crystal structure, π-π stacking inter-actions [centroid-centroid distances = 3.4736 (19) and 3.5416 (19) Å] and weak N-H⋯N and N-H⋯Br inter-actions contribute to the stability of the structure.
متن کاملMolecular docking studies on quinazoline antifolate derivatives as human thymidylate synthase inhibitors
We have performed molecular docking on quinazoline antifolates complexed with human thymidylate synthase to gain insight into the structural preferences of these inhibitors. The study was conducted on a selected set of one hundred six compounds with variation in structure and activity. The structural analyses indicate that the coordinate bond interactions, the hydrogen bond interactions, the va...
متن کاملNew studies on trans-anethole oxide and trans-asarone oxide.
The widespread use of naturally occurring alkenylbenzenes as flavoring and fragrance agents has led to a long-standing interest in their toxicity and carcinogenicity. Among them several allyl- and propenylbenzenes have been found to be mutagenic and carcinogenic. It has been shown that the carcinogenicity of several allylbenzenes can be related to the formation of electrophilic sulfuric acid es...
متن کاملStudies on 3-methoxyproline and 3-hydroxyproline.
The cis and trans racemates of synthetic 3-hydroxyproline and of synthetic 3-methoxyproline were interconverted by an epimerization reaction at carbon atom 2. The interconversions are proof of the diastereomeric nature of the synthetic isomers. Assignments of cis and trans configuration were made from nuclear magnetic resonance studies. Synthetic cisand trans-3-hydroxy-DL-proline were partially...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1961
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.9.635