Studies on Pyrazolo [3, 4-d] pyrimidine Derivatives. II. On the Reaction of 4-Chloro-1-methyl-1H-pyrazolo [3, 4-d] pyrimidine with Ketone Carbanion
نویسندگان
چکیده
منابع مشابه
7-Chloro-5-(2-ethoxyphenyl)-1-methyl-3-propyl-2,6-dihydro-1H-pyrazolo[4,3-d]pyrimidine
In the title compound, C(17)H(21)ClN(4)O, the benzene ring is oriented at dihedral angles of 1.59 (3) and 1.27 (3)° with respect to the pyrimidine and pyrazole rings, while the dihedral angle between the pyrimidine and pyrazole rings is 0.83 (3)°. An intra-molecular N-H⋯O hydrogen bond results in the formation of a planar (r.m.s. deviation 0.004 Å) six-membered ring.
متن کامل4-Chloro-1H-pyrrolo[2,3-d]pyrimidine
The title compound, C(6)H(4)ClN(3), is essentially planar with the pyrrole and pyrimidine rings inclined to one another by 0.79 (15)°. In the crystal, mol-ecules are connected via pairs of N-H⋯N hydrogen bonds, forming inversion dimers. These dimers are linked via C-H⋯N inter-actions, forming a two-dimensional network parallel to (10-1).
متن کامل4-(4-Chloro-5-methyl-3-trifluoromethyl-1H-pyrazol-1-yl)-6-(prop-2-ynyloxy)pyrimidine
The molecule of the title compound, C(12)H(8)ClF(3)N(4)O, is twisted as indicated by the C-O-C-C torsion angle of 76.9 (3)°. Moreover, the trifluoro-methyl group shows rotational disorder of the F atoms, with site-occupancy factors of 0.653 (6) and 0.347 (6). The dihedral angle between the rings is 1.88 (12) Å.
متن کامل5-Butylamino-6-(4-fluorophenyl)-7-oxo-1-p-tolyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carbonitrile
In the title compound, C(23)H(21)FN(6)O, the dihedral angle between the fluoro-phenyl and pyrimidinone rings is 75.9 (1)°, and the dihedral angle between the methyl-phenyl and pyrazole rings is 40.3 (1)°. In the crystal structure, weak C-H⋯π(arene) and C-N⋯π(arene) inter-actions and intermolecular C-H⋯N and N-H⋯O hydrogen-bonding inter-actions are present.
متن کامل4-(4-Bromo-3-methyl-1H-pyrazol-1-yl)-6-(but-3-ynyloxy)pyrimidine
There are two mol-ecules in the asymmetric unit of the title compound, C(12)H(11)BrN(4)O. The dihedral angles between the pyrazole and pyrimidine rings are 1.28 (17) and 1.56 (17)° in the two mol-ecules. In one of the mol-ecules, the but-3-yn-yloxy side chain is disordered over two sets of sites in a 0.714 (8):0.286 (8) ratio.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1974
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.94.10_1191