Studies on Phenolic Lactones

Studies on phenolic steroids in human subjects.

Hologram QSAR studies of antiprotozoal activities of sesquiterpene lactones.

Infectious diseases such as trypanosomiasis and leishmaniasis are considered neglected tropical diseases due the lack for many years of research and development into new drug treatments besides the high incidence of mortality and the lack of current safe and effective drug therapies. Natural products such as sesquiterpene lactones have shown activity against T. brucei and L. donovani, the paras...

Lactones 5 * . Synthesis of Some Terpenoid Lactones from , - Epoxy Esters

Synthesis of bicyclic [1] and tricyclic [2] terpenoid lactones and the preliminary results of biological tests for their feeding deterrent activity [3] previously were presented. The tests, which were carried out on three storage pest insects: the grain weevil (Sitophilus granarius L.), the confused flour beetle (Tribolium confusum Duv.) and the khapra beetle (Trogoderma granarium Ev.), showed ...

Toxicity of some phenolic derivatives--in vitro studies.

Cytotoxicity of 5 phenol derivatives (phenol, catechol, resorcinol, hydroquinone and phloroglucinol) was tested using a mouse 3T3 fibroblast cell line. Its relationships with structural and physicochemical properties were investigated. Linear regression analysis and Pearson's correlation coefficient were used to characterise the relationship between cytotoxicity (expressed by IC(50) values) and...

Environmental fate of phenolic endocrine disruptors: field and laboratory studies.

Alkylphenolic compounds derived from microbial degradation of non-ionic surfactants became a major focus of environmental research in the early 1980s. More toxic than the parent compounds and weakly oestrogenic, certain metabolites of nonylphenol polyethoxylate (NPnEO) surfactants, especially nonylphenol (NP), raised sustained concern over the risk they pose to the environment and triggered leg...