Studies on neurotrophic and substrate — attached neurite outgrowth factors
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چکیده
منابع مشابه
Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds.
Neurotrophic factors present as concentration gradients are neurotropic cues that direct axonal growth toward their targets. Multiple factors work together in vivo to ensure axons reach the proper targets, likely interacting with one another via intracellular signalling pathways. Nerve growth factor (NGF) and neurotrophin-3 (NT-3) are neurotrophins known to guide axons as well as promote axonal...
متن کاملStudies on extracellular matrix components that promote neurite outgrowth.
A University of California author or department has made this article openly available. Thanks to the Academic Senate's Open Access Policy, a great many UC-authored scholarly publications will now be freely available on this site. Let us know how this access is important for you. We want to hear your story! Title: Studies on extracellular matrix components that promote neurite outgrowth.
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Stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) are initially discovered as the essential hematopoietic growth factors regulating bone marrow stem cell proliferation and differentiation, and SCF in combination with G-CSF (SCF+G-CSF) has synergistic effects on bone marrow stem cell mobilization. In this study we have determined the effect of SCF and G-CSF on neurite outg...
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Despite nerve-sparing radical prostatectomy, nerve damage and erectile dysfunction (ED) prevail, and preventing neurodegeneration is of great importance. Neurotrophic factors and neurite outgrowth were characterized in major pelvic ganglia (MPG) following bilateral cavernous nerve injury (BCNI). Young male Sprague-Dawley rats underwent sham or BCNI surgery, and the intracavernosal pressure to m...
متن کاملJ1/tenascin in substrate-bound and soluble form displays contrary effects on neurite outgrowth
The influence of J1/tenascin adsorbed to polyornithine-conditioned plastic (substrate-bound J1/tenascin) and J1/tenascin present in the culture medium (soluble J1/tenascin) on neurite outgrowth was studied with cultured single cells from hippocampus and mesencephalon of embryonic rats. Neurons at low density grew well on J1/tenascin substrates and extended neurites that were approximately 40% l...
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ژورنال
عنوان ژورنال: International Journal of Developmental Neuroscience
سال: 1983
ISSN: 0736-5748,1873-474X
DOI: 10.1016/0736-5748(83)90235-6