Studies on Methyl Transfer from 5,6-Dimethylbenzimidazolylcobamide Methyl (Methyl-B12) to Homocysteine
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چکیده
منابع مشابه
Folate, vitamin B12, homocysteine and methylenetetrahydrofolate reductase (MTHFR) are involved in one-carbon transfer (methyl-
reductase (MTHFR) are involved in one-carbon transfer (methylation) reactions necessary for the production of monoamine neurotransmitters, phospholipids and nucleotides. Folate and vitamin B12 deficiency, hyperhomocysteinaemia and the T677 allele of the MTHFR gene, which cause impaired methylation reactions in the central nervous system, have been associated with depressive disorders. However n...
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The transfer of the methyl group from methylcobalamin to diaquocobinamide in aqueous solution has been demonstrated by proton, carbon-13, and phosphorus-31 nuclear magnetic resonance spectroscopy. The products of this reaction are aquocobalamin and the methylaquocobinamides. Dicyanocobinamide and the cyanoaquocobinamides do not serve as methyl acceptors, while ligands such as pyridine and histi...
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Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B12-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H₂S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenos...
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In the title compound, C(9)H(8)N(2)O(6), the methyl ester group is almost planar (r.m.s. deviation = 0.002 Å) and is oriented at a dihedral angle of 24.27 (16)° with respect to the benzene ring. The nitro groups make dihedral angles of 4.2 (5)° and 60.21 (11)° with the benzene ring. In the crystal, mol-ecules are linked by C-H⋯O inter-actions, resulting in zigzag chains.
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Jasmonate compounds are known as new plant hormones that play important roles in the regulation of plant growth and development. Mints have been used and valued as aromatic herbs for thousands of years. Peppermint (Mentha piperita L.) is used for medicinal and food purposes and its essential oil is considered industrially important. Peppermint plants were grown in a greenhouse in pots. At flowe...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1964
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)91288-3