Studies on Lankacidin-Group (T-2636) Antibiotics. V. Chemical Structures of Lankacidin-Group Antibiotics. (1)
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منابع مشابه
Inclusion compounds of lankacidin-group antibiotics with cyclodextrins.
Lankacidin-group antibiotics formed inclusion compounds with beta-cyclodextrin in molar ratios of about 1:1. These compounds showed remarkably improved water-solubility and stability in aqueous solutions. The structure of the inclusion compounds of lankacidin A is proposed based on the facility of their inclusion with beta-cyclodextrin and the results of 1H NMR spectral studies.
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The new, belonging to the streptothricin-group antibiotics AN-201 I, II and III were found to be produced by a soil actinomycete identified as Streptomyces nojiriensis C-13. The chemical structures and the physical and spectroscopic properties of these compounds are reported here. On the basis of NMR and fast atom bombardment mass spectrometry (FAB-MS) spectra the antibiotics were identified as...
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The structures of the large ribosomal subunit of Deinococcus radiodurans (D50S) in complex with the antibiotic lankamycin (3.2 Å) and a double antibiotic complex of lankamycin and lankacidin C (3.45 Å) have been determined, in continuation of previous crystallographic studies on lankacidin-D50S complex. These two drugs have been previously reported to inhibit ribosomal function with mild synerg...
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Fermentati on The inoculum for antibiotic production was prepared in a medium containing glucose 2%, peptone 0.5%, meat extract 0.5%, dry yeast 0.3%, NaCl 0.5%, CaCO3 0.3% (ajusted to pH 7.0 before sterilization). A 250-ml Erlenmeyer flask containing 30ml of this medium was inoculated from a slant of Streptomyces sp. No. 83-16. The flask was incubated at 28°C on a rotary shaker at 220rpm for 72...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1974
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.22.99