Studies on eye irritation caused by chemicals in rabbits. III. An in vitro testing method using rat red blood cells for the prediction of eye irritation potential of chemicals.
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چکیده
منابع مشابه
In silico prediction of serious eye irritation or corrosion potential of chemicals
Rapidly and correctly identifying eye irritants or corrosive chemicals is an important issue in health hazard assessment. The purpose of this study is to describe the development of in silico methods for the classification of chemicals into irritants/corrosives or non-irritants/non-corrosives. A total of 5220 chemicals for a serious eye irritation (EI) dataset and 2299 chemicals as an eye corro...
متن کاملEye irritation hazard of chemicals and formulations assessed by methods in vitro.
BACKGROUND The aim of this study was to compare human and animal skin irritation data with results of selected in vitro methods, including HET-CAM test, Neutral Red Release Assay, Neutral Red Uptake Assay and EpiOcular eye irritation test and with already existing data of eye irritation obtained from animal experiments. METHODS Chemicals employed in previous skin irritation validation studies...
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this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...
Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model.
To comply with the Seventh Amendment to the EU Cosmetics Directive and EU REACH legislation, validated non-animal alternative methods for reliable and accurate assessment of ocular toxicity in man are needed. To address this need, we have developed an eye irritation test (EIT) which utilizes a three dimensional reconstructed human cornea-like epithelial (RhCE) tissue model that is based on norm...
متن کاملCON4EI: CONsortium for in vitro Eye Irritation testing strategy - EpiOcular™ time-to-toxicity (EpiOcular ET-50) protocols for hazard identification and labelling of eye irritating chemicals.
Assessment of acute eye irritation potential is part of the international regulatory requirements for testing of chemicals. The objective of the CON4EI (CONsortium for in vitro Eye Irritation testing strategy) project was to develop tiered testing strategies for eye irritation assessment for all drivers of classification. A set of 80 reference chemicals (38 liquids and 42 solids) was tested wit...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1991
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.16.131