Studies on Experimental Diabetes

Experimental Studies on Diabetes

1. The injurious effects of excessive carbohydrate diet are demonstrable in partially depancreatized dogs, in the same manner as in human patients. With severe diabetes there is rapid progress of emaciation and weakness and early death. 2. With milder diabetes, there is frequently a transitional state following operation, when the fate depends on the diet. If the tolerance is spared for a time,...

Studies on Experimental Diabetes

Experimental diabetes has been characterized as a metabolic state involving both overproduction and underutilization of glucose. Although these changes have been recognized for many years, the specific biochemical alterations resulting in increased hepatic glucose production have not been adequately described. The adrenal cortical steroids are known, however, to have an important role in the re...

Studies on experimental diabetes. II. Carbon dioxide fixation.

[experimental Studies of Steroid Diabetes in Rats].

It is well known that adrenal corticosteroids have many biological effects on the carbohydrate metabolism. However, the mechanism of corticosteroids on carbohydrate metabolism has not been completely clarified and remains to be studied. In the present investigation, it was intended to study the effects of dietary carbohydrates on the experimental steroid diabetes induced by Ingles method in whi...

Experimental Studies on Inflammation

1. Wright's method for the study of chemotaxis of leucocytes in vitro, slightly modified, has been found to be most satisfactory in the estimation of the degree of chemotaxis of various substances, because it is possible to make an exact quantitative determination of the leucocytes that have migrated from the blood clot and adhere to the surfaces containing the tested substance. 2. The calcium ...