Studies on drug dependence (Report 23)
نویسندگان
چکیده
منابع مشابه
Pharmacological studies on drug dependence in rodents: dependence on opioids and CNS depressants.
Physical and psychic dependence on opioids and CNS depressants in rodents were examined using the drug-admixed food (DAF) method. A comparison of several methods for developing physical dependence on opioids was made. The DAF method has the advantage of rapidly inducing a high degree of physical dependence without causing morbidity or mortality. When morphine-dependent rats were pretreated with...
متن کاملCommentary: New View on Treatment of Drug Dependence
In the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. In this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. However, no positive results obtain...
متن کاملLoperamide Dependence: A Case Report
Background: Loperamide is used as an antidiarrheal drug and is available over-the-counter. It cannot pass the blood-brain barrier and it does not have a considerable abuse potential. It can lead to dangerous cardiac arrhythmia.Case Report: Herein, we report a 35-year-old man with a 13-year history of abusing opioids who had undergone detoxification for four times during this period. He underwen...
متن کاملEvaluation on drug dependence of buprenorphine.
AIM To survey and assess the drug dependence and abuse potential liability of buprenorphine among opiate abusers. METHODS Subjects of opiate dependence with history of buprenorphine use for 3 d at least were surveyed by interview. Physical dependence of buprenorphine was assessed using 30 items opiate withdrawal scale (OWS), which composed of 30 symptoms/signs. A 4-point scale was used to rat...
متن کاملNew View on Treatment of Drug Dependence
In the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. In this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. However, no positive results obtain...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1976
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)65908-1