Studies on Chemotherapeutics. XLI

Xxxviii. Studies in the Biochemistry of Micro-organisms. Xli. the Metabolic Products of Penicillium

IN a recent communication [Clutterbuck et al., 1934] it was shown that Penicillium Charlesii G. Smith, a new species of Penicillium isolated by our late colleague Mr J. H. V. Charles from mouldy Italian maize, produced from glucose a polygalactose and a polymannose together with a number of hitherto undescribed organic acids. Of these acids carolic and carolinic acids were obtained in the large...

Antifungal chemotherapeutics.

This review addresses trends in outcome and risk factors for invasive fungal infections, current antifungal agents and new therapeutic strategies. Current prospects for new therapies rest upon caspofungin, the first of a new class of antifungal molecules, the echinocandins, and new extended-spectrum azoles, voriconazole, posaconazole and ravuconazole. Approval by the Food and Drug Administratio...

Xli. Gas-electrode for General Use

Nanoformulations of Antimicrobial Chemotherapeutics

Bacterial infections represent an increasing worldwide threat. The number of untreatable diseases decreased after the 1950s due to the introduction of antimicrobial agents. However, since the 1980s, morbidity has risen again, and mortality due to respiratory infections, AIDS and tuberculosis now represents about 85% of world mortality from infections [1,2]. The increase in the number of new inf...

Integrin Targeted Delivery of Chemotherapeutics

Targeted delivery of chemotherapeutics is defined in the sense, that is, to maximize the therapeutic index of a chemotherapeutic agent by strictly localizing its pharmacological activity to the site or tissue of action. Integrins are a family of heterodimeric transmembrane glycoproteins involved in a wide range of cell-to-extracellular matrix (ECM) and cell-to-cell interactions. As cell surface...