Studies on Chemotherapeutics. XIX

Studies on Copper Metabolism. Xix

Ferrokinetic studies were performed in three copper-deficient swine and the results have been compared with similar studies in 18 normal pigs. The mean value for the plasma iron turnover rate in the deficient swine was 1.76 mg./kg. day; for the red cell iron incorporation rate, 1.24 mg./kg. day; for the red cell iron turnover rate, 1.18 mg./kg. day; for the red cell life span, 13 days. Correspo...

Studies of drugs given before anaesthesia. XIX. The opiates.

Using Ridit analysis, a comparison was made of the overall effects of what are generally considered to be equianalgesic doses of sixteen opiates, with respect to their desired and toxic effects when given as premedication to a standard population. Four mixtures of opiates, the non-opiate diazepam and saline were also included in the analysis. Results with all individual drugs have been previous...

Immunochemical studies of organ and tumor lipids . XIX . Cytolytic

Rabbit antisera to rat lymphosarcoma contain antibodies that are cytolytic for rat erythrocytes in the presence of complement. The reaction can be inhibited completely by pure cytolipin R showing that (u) immune hemolysis can be mediated through lipid determinants in the membrane, and ( b ) that cytolipin R determinants are present in the intact erythrocyte membrane and exposed on the surface. ...

Studies on echinococcosis. XIX. Heat stable antigen in cystic fluid of Echinococcus multilocularis.

Antifungal chemotherapeutics.

This review addresses trends in outcome and risk factors for invasive fungal infections, current antifungal agents and new therapeutic strategies. Current prospects for new therapies rest upon caspofungin, the first of a new class of antifungal molecules, the echinocandins, and new extended-spectrum azoles, voriconazole, posaconazole and ravuconazole. Approval by the Food and Drug Administratio...