Studies on Chemotherapeutics. III

Antifungal chemotherapeutics.

This review addresses trends in outcome and risk factors for invasive fungal infections, current antifungal agents and new therapeutic strategies. Current prospects for new therapies rest upon caspofungin, the first of a new class of antifungal molecules, the echinocandins, and new extended-spectrum azoles, voriconazole, posaconazole and ravuconazole. Approval by the Food and Drug Administratio...

Studies on Plasma Protein. III. Malaria

Two distinct groups of cases were encountered during the study of plasma proteins in malarial patients. One was acute malaria, which showed all the features of an acute febrile infection. The other was chronic relapsing malaria, some cases were inadequately treated, and many had : hepatomegaly and splenomegaly. Plasma proteins of 40 patients, admitted in the hospital, were studied and in all of...

Studies on Complement Fixation in Tuberculosis. Iii

The prolonged extraction of the tubercle bacillus with boiling ethyl alcohol, followed by one or more reprecipitations by chilling the hot alcoholic solution, easily yields a preparation very active as antigen in the complement fixation reaction. This preparation gives a precipitation reaction with high dilution of the normal blood serum of a number of species. The precipitation reaction presen...

Clxxxi . Studies on Diffusing Factors . Iii

THE presence of diffusing factors in snake venoms has been demonstrated by Duran-Reynals [1936, 1939]. The immediate effect of intracutaneous injection of indicator solutions containing rattlesnake venom is similar to that of solutions containing testicular diffusing factor [Madinaveitia, 1939], namely,. an almost instantaneous flattening of the resulting bleb with rapid spread of the indicator...

Pigs Experimental Studies in Guinea Studies on Mumps Virus: Iii