Studies on benzylation of phenolic hydroxyl groups.
نویسندگان
چکیده
منابع مشابه
Phenolic hydroxyl ionization in papain.
Various properties of crystalline papain have been under investigation in this laboratory for several years in attempts to understand the specificity, mode of action, and other aspects of the behavior of this enzyme (1). Inasmuch as papain must be in its native state to retain its enzymic activity, a knowledge of the role of the amino acid side chains in maintaining conformation is essential. T...
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A series of novel chiral ruthenium(II) complexes with phenolic hydroxyl groups were synthesized and characterized. These ruthenium(II) complexes exhibited strong dual inhibition of topoisomerases I and IIα, with approximate IC50 values of 3-15 mM, which were more efficient than the widely clinically used single TopoI poison camptothecin (CPT) or TopoIIα poison etoposide (VP-16). Δ-1 and Λ-1 wit...
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The synthesis of cis-N-[a-carbobenzyloxy-b-(p-hydroxyphenyl)ethyl]-3-phthalimido-4-styryl-2-azetidinone is described. We have found that the electron-rich Schiff bases can afford the cis-b-lactam ring even in the presence of the free hydroxyl functions. The mechanisms of cis and trans-b-lactam ring formation are discuss...
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A highly efficient, two-step sequence method for the deoxygenation of hydroxyl groups has been developed. The method involves the preparation of the 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol using methyl dichlorophosphite and 2-(2-iodophenyl)ethanol. Treatment of the phosphite intermediate with (n-Bu)3SnH/AIBN in refluxing benzene cleanly produces the deoxygenation product...
متن کاملDevelopment of hydrophilic photolabile hydroxyl protecting groups.
Hydrophilic photolabile protecting groups (PPGs) for hydroxyl protection have been developed. The new PPGs are derived from 3-(dimethylamino)trityl (DMATr) by replacing the two methyl groups with two hydrophilic butyryl groups. The new PPG reagents can be readily prepared and installed. They are stable in the dark but can be removed cleanly and efficiently in aqueous environments upon irradiati...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 1979
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.55.165