Studies on 1-Alkenyl Isocyanates. VI-VII. VII. Reactions of 1-Alkenyl Isocyanates with Alcohols or Mer captans

Gold-catalysed alkenyl- and arylsilylation reactions forming 1-silaindenes.

In the presence of gold(I)-phosphine catalysts, alkenyl- and arylsilanes undergo intramolecular cyclisation reactions onto appendant alkyne moieties to afford 1-silaindene derivatives. The reaction pathways vary depending on the substituent on silicon.

Ruthenium-catalyzed transformation of alkenyl triflates to alkenyl halides.

In the presence of a ruthenium catalyst, alkenyl triflates were found to be transformed to the corresponding bromides, chlorides and iodides simply by treatment with a lithium halide (1.2 equiv.).

Carbolithiation of N-alkenyl ureas and N-alkenyl carbamates

N-Alkenyl ureas and N-alkenyl carbamates, like other N-acyl enamines, are typically nucleophilic at their β-carbon. However, by incorporating an α-aryl substituent, we show that they will also undergo attack at the β-carbon by organolithium nucleophiles, leading to the products of carbolithiation. The carbolithiation of E and Z N-alkenyl ureas is diastereospecific, and N-tert-butoxycarbonyl N-a...

Ii Iii Iv V Vi Vii a B C Ii Iii Iv V Vi Vii A

A novel X-linked combined immunodeficiency disease was found in five living males in an extended family in the United States. The age of the affected males ranged from 2.5 to 34 yr. The most prominent clinical abnormalities were a paucity of lymphoid tissue; recurrent sinusitis, otitis media, bronchitis, and pneumonia; severe varicella; and chronic papillomavirus infections. The principal immun...

Zirconocene-catalyzed reactions of alkenyl-substituted enol ethers.