STUDIES OF PPLO INFECTION

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Studies of Pplo Infection

Rolling disease has been produced and studied in rats and mice, using the exotoxin of the A strain of Mycoplasma neurolyticum. The primary lesion of the brain consists of spongiform degeneration, associated with vesicle formation in the cortex and underlying white matter of the cerebral hemispheres, and in the molecular layer of the cerebellum. The brains of animals surviving 2 days or longer s...

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STUDIES OF PPLO INFECTION V. INHIBITION O]g LYMPHOCYTE MITOSIS AND ANTIBODY FORMATION

Inhibition of the mitotic reaction of lymphocytes to phytohemagglutinin (PHA) by certain species of mycoplasmas was described by Copperman and Morton (1). These investigators showed that suspensions of whole mycoplasmas, as well as aqueous extracts of frozen-thawed organisms (2), prevented the reaction while in contact with the cells; reactivity was restored when the lymphocytes were washed. In...

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STUDIES OF PPLO INFECTION II. THE NEUROTOXlN OF M¥COPLASMA NEUROLYTICUM

Mycoplasma neurolyticum was identified as the cause of "rolling disease" in mice by Sabin (1) and Findlay et al. (2) in 1938. These investigators encountered the agent in the course of intracerebral passages of mouse brain homogenates in mice. The neurological syndrome was bizarre and unique, characterized by the abrupt onset of continual rolling movements to one side or the other, persisting f...

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Pleuropneumonia-Like Organisms (PPLO) Mycoplasmataceae

This small book is an attempt to review present knowledge on the morphology, immunology, and pathogenicity of the pleuropneumonia-like organisms (PPLO). The author is a recognized authority on these organisms and the material is presented from her point of view, although she readily admits that there are some who may be in disagreement with her conclusions. Four of the eleven chapters are devot...

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Pplo of Human Genital Origin

Pleuropneumonia-like organisms (PPLO) have frequently been isolated from the human genital tract since the first report by Dienes and Edsall (1937); their presence in the urethral discharge of patients with non-gonococcal urethritis (N.G.U.) aroused interest because of the unknown aetiology of the disease. The significance ofPPLO in the genital tract and their association with N.G.U. are disput...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1969

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.129.6.1163