Studies in penicillin production by Penicillium notatum, in surface culture
نویسندگان
چکیده
منابع مشابه
Microbiological Aspects of Penicillin: III. Production of Penicillin in Surface Cultures of Penicillium notatum.
Steadily increasing interest in penicillin as a chemotherapeutic agent has led to a parallel increase in the demand for penicillin for clinical application and chemical studies. Penicillin is produced in minute quantities by Penicillium notatum so that filtrates from the mold represent exceedingly dilute solutions of penicillin from which the active agent is extracted. The magnitude of the prob...
متن کاملStudies in penicillin production by Penicillium notatum, in surface culture: 1. A preliminary study of the metabolism of carbon, nitrogen, sulphur and phosphorus.
An earlier report from these laboratories described the metabolism of carbon and nitrogen compounds by Penicillium notatum in surface culture (Hockenhull, 1946), and some references were made to the utilization of sulphur by this organism. Further work on the latter aspect seemed desirable, especially as penicillin is a sulphur-containing compound. It is the purpose of the present communication...
متن کاملA Comparison of Penicillin-producing Strains of Penicillium notatum-chrysogenum.
Sampling and storage. The fermentations were conducted in the 100-gallon tanks described by Stefaniak et al. (1946). Samples were removed periodically into 500-ml flasks and ifitered. A 0.5-ml filtered sample was immediately diluted for penicillin assay by addition to previously chilled phosphate buffer in volumetric flasks (4.0 g KH2P04 and 1.0 g K2HPO4 per 500 ml solution in distilled water; ...
متن کاملProduction of Conidia in Submerged Cultures of Penicillium notatum.
Foster, McDaniel, Woodruff, and Stokes (1945) recently described the formation of conidia by molds of the genus Penicillium during submerged growth in liquid culture media. Controlling or associated factors for this phenomenon were described as the presence of a rather high calcium-ion concentration and, in general, the development of considerably less mycelium before spore formation than is fo...
متن کاملPenicillin production by wild isolates of Penicillium chrysogenum in Pakistan
The present study was aimed at exploring the native wild isolates of Penicillium chrysogenum series in terms of their penicillin production potential. Apart from the standard medium, the efforts were made to utilize suitable agro-industrial wastes for the maximum yield of penicillin. Two series of P. chrysogenum were isolated from local sources and named as P. chrysogenum series UAF R1 and P. c...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1946
ISSN: 0306-3283
DOI: 10.1042/bj0400337