Structures and Syntheses of Leupeptins Pr-LL and Ac-LL

Angei'iandte Ratlrtrf-\nnr= Tt -l -ll Jttul Ll Ll =

Synthetic studies on leupeptins and their analogs.

Leupeptins, fermentation products of various strains of Actinomycetes^ showed strong antiplasmin activity2) and were identified as being a mixture of two major components, leupeptin Ac-LL (acetyl-L-leucyl-L-leucyl-DL-argininal, 1) and leupeptin Pr-LL (propionyl-L-leucyl-L-leucyl-DL-argininal, 2), and their analogs containing isoleucine or valine in place of one or two leucine residues of 1 or 2...

Unifying LL and LR parsing

In parsing theory, LL parsing and LR parsing are regarded to be two distinct methods. In this paper the relation between these methods is cla-riied. As shown in literature on parsing theory, for every context-free grammar, a so-called non-deterministic LR(0) automaton can be constructed. Here, we show, that traversing this automaton in a special way is equivalent to LL(1) parsing. This automato...

Divergent syntheses of resorcylic acid lactones: L-783277, LL-Z1640-2, and hypothemycin.

The resorcylic acid lactones (RAL) are endowed with diverse biological activity ranging from transcription factor modulators (zearalenone and zearalenol) to HSP90 inhibitors (radicicol and pochonin D) and reversible (aigialomycin D) as well as irreversible kinase inhibitors (hypothemycin and other RAL containing a cis-enone). Our interest in broadening the diversity of this family beyond natura...

lL - 8 induces T cell chemotaxis , suppresses lL - 4 , and up - regulates lL - 8 production by CD 4 T cells

Interleukin-8 (IL-8), a neutrophil-activatbig cytokine, also activates certain T cell functions such as chemotaxis. We additionally find (n 6) that recombinant (rIL-8; 1-100 ng/ml), when added to 24 h culture of human CD4 T cells, suppressed the spontaneous production of IL-4 (50-85%). Steady state production of IL-4 was typically around 30 pg/nil, determined by use of a solidphase immunoabsorb...