Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells

Review of Prodigiosin, Pigmentation in Serratia marcescens

Prodigiosins, a family of natural red pigments characterized by a common pyrrolylpyrromethane skeleton, are produced by various bacteria that first characterized from Serratia marcescens. This pigment is a promising drug owing to its reported characteristics of having antifungal, immunosuppressive and anti-proliferative activity. From an industrial point of view to obtain optimal conditions to ...

Spray-dried Prodigiosin from Serratia marcescens As A colorant

Encapsulation technique via spray drying can be employed to enhance the natural pigment’s properties. In this study, spray-dried microparticles containing red pigment (prodigiosin) extracted from Serratia marcescens was produced using κcarrageenan and maltodextrin as encapsulation agents. The effect of spray-drying parameters on the encapsulation yield (EY), particle size and color intensity of...

Effect of polymyxin B on the synthesis of prodigiosin and its precursors in Serratia marcescens.

Biosynthesis of prodigiosin, a secondary metabolite of Serratia marcescens.

Prodigiosenes (prodigiosin and prodigiosin-like pigments) are known to be synthesized by only one genus of Eubacteriales and by two genera of Actinomycetales. Biosynthesis by Serratia marcescens occurs over a relatively narrow range of temperatures, although the bacteria grow over a broad range. When cultures of S. marcescens were incubated at 27 C in 1.0% casein hydrolysate, viable count and p...

Defects in prodigiosin formation by L-forms of Serratia marcescens.

An L-form of Serratia marcescens has previously been shown incapable of producing the red pigment, prodigiosin, characteristic of the parent bacteria. Mutants of S. marcesens, unable to form one or the other of the two prodigiosin precursors, 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde or 2-methyl-3-n-amylpyrrole, were used to test the nature of the L-form defect. The L-forms failed to form suffi...