Structure, dynamics and function of nuclear pore complexes
نویسندگان
چکیده
منابع مشابه
Structure, dynamics and function of nuclear pore complexes.
Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope, thereby connecting the nuclear interior with the cytoplasm. Until recently, these macromolecular complexes were viewed as static structures, the only function of which was to control the molecular trafficking between the two compartments. It has now become evident that this simplistic scenario is inaccurate a...
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In vivo studies on the dynamics of the nuclear pore complex (NPC) in yeast suggested that NPCs are highly mobile in the nuclear envelope. However, new evidence indicates that in mammalian cells NPCs are stably attached to a flexible lamina framework, but a peripheral component can exchange rapidly with an intranuclear pool.
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What do they look like? A picture is worth twice the length of this article (Figure 1). All eukaryotes have these impressive structures: vertebrates have the Cadillac model (~125 MDa) and yeast a sportier version (~50 MDa). In spite of their immense size, these structures are made of a relatively small number of proteins — about 30 — the so-called nucleoporins or nups. Defining an NPC ‘interact...
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While much is known about the role of nuclear pore complexes (NPCs) in nucleocytoplasmic transport, the mechanism of NPC assembly into pores formed through the double lipid bilayer of the nuclear envelope is not well defined. To investigate the dynamics of NPCs, we developed a live-cell assay in the yeast Saccharomyces cerevisiae. The nucleoporin Nup49p was fused to the green fluorescent protei...
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Javier Fernandez-Martinez1,7, Seung Joong Kim2,7, Yi Shi3,7, Paula Upla4,7, Riccardo Pellarin2,6,7, Michael Gagnon5, Ilan E. Chemmama2, Junjie Wang3, Ilona Nudelman1, Wenzhu Zhang3, Rosemary Williams1, William J. Rice4, David L. Stokes4, Daniel Zenklusen5, Brian T. Chait3,*, Andrej Sali2,*, and Michael P. Rout1,* 1Laboratory of Cellular and Structural Biology, The Rockefeller University, New Yo...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2008
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2008.07.009