Structure and function of claudins

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Structure and function of claudins.

Claudins are tetraspan transmembrane proteins of tight junctions. They determine the barrier properties of this type of cell-cell contact existing between the plasma membranes of two neighbouring cells, such as occurring in endothelia or epithelia. Claudins can completely tighten the paracellular cleft for solutes, and they can form paracellular ion pores. It is assumed that the extracellular l...

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ژورنال

عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes

سال: 2008

ISSN: 0005-2736

DOI: 10.1016/j.bbamem.2007.10.018