Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein
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چکیده
منابع مشابه
The Human Mannose-binding Protein Gene
The human mannose-binding protein (MBP)' is an acute phase serum protein of -300 kD comprised of multimers of a 32-kD subunit (1-3). It is a member of an ever-growing family of animal lectins that share at least 18 invariant residues in their carbohydrate recognition domain (CRD). The family can be divided into membrane proteins and soluble proteins, and all bind ligands optimally at neutral pH...
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The human mannose-binding protein (MBP) plays a role in first line host defense against certain pathogens. It is an acute phase protein that exists in serum as a multimer of a 32-kD subunit. The NH2 terminus is rich in cysteines that mediate interchain disulphide bonds and stabilize the second collagen-like region. This is followed by a short intervening region, and the carbohydrate recognition...
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background: acanthamoeba castellanii is the important cause of amoebic keratitis in iran. the key molecule in pathogenesis of acanthamoeba keratitis is mannose binding protein (mbp) led to adhesion of amoeba to corneal epithelium. subsequent to adhesion other cytopathic effects occur. the goal of this study was to identify the molecular characterization of a gene encoding mbp in an iranian is...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1989
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2620763