STRUCTURE-ACTIVITY RELATIONSHIPS FOR THE ANTICHOLINOCEPTOR ACTION OF TRICYCLIC ANTIDEPRESSANTS

Tricyclic antidepressants.

Tricyclic antidepressants.

Correspondence BRiTISH 301 Tricyclic Antidepressants SIR,-I am worried by one sentence in the article on tricyclic antidepressants (13 April, p. 102): "Jaundice, which is very uncommon , is of the cholestatic type similar to that found in chlorpromazine." This is misleading. Jaundice is one of the more frequent side-effects reported from imipramine and imitrip-tyline, the most widely used membe...

Pharmacokinetics of Tricyclic Antidepressants

This review, together with Part 1 (Gun. Chem. 26: 5-17, 1980), summarizes progress in measurement of tricyclic antidepressants in biological fluids and the application of the methodology to Clinical practice. For many of the older drugs and for all of the new-generation antidepressants, further studies are required to delineate the precise relationship between plasma concentration and clinical ...

lacental Passage of Tricyclic Antidepressants

ackground: The use of antidepressants during pregnancy continues to garner considerable attention, though there are limited nvestigations that have sought to quantify fetal exposure. ethods: Maternal and umbilical cord sera were collected at delivery from ten women taking nortriptyline and seven taking lomipramine. Placental passage was calculated as the ratio of umbilical cord to maternal seru...

Tricyclic antidepressants for preventing migraine in adults

BACKGROUND Migraine, ranked as the 7th-highest specific cause of disability worldwide, has caused an enormous burden on the economy and society. Tricyclic antidepressant (TCA) is one of the most commonly drugs for migraine prevention. However, evidence about the efficacy and tolerability of TCAs in the prophylaxis of migraine in adults is somewhat confusing. METHODS A computerized literature ...