Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11
نویسندگان
چکیده
منابع مشابه
Signal transduction of interleukin-11 and interleukin-6 α-receptors
The cytokines Interleukin (IL)-11 and IL-6 are important mediators that regulate differentiation and proliferation of immune cells. Both cytokines bind to unique non-signaling α-receptors (IL-11R and IL-6R, respectively), and the resulting cytokine/cytokine receptor complexes recruit a homodimer of the signal-transducing β-receptor glycoprotein (gp)130. Gp130 is expressed ubiquitously, whereas ...
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G ROWTH AND DIFFERENTIATION of cells in the immune and hematopoietic systems are regulated by cytokines or interleukins. One of the characteristic features of cytokines is their functional pleiotropy and redundancy, ie, one cytokine shows a wide variety of biologic functions on various tissues and cells, and several different cytokines exert similar and overlapping functions on a certain cell. ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.01424