منابع مشابه
Structure and Behavior of Human α-Thrombin upon Ligand Recognition: Thermodynamic and Molecular Dynamics Studies
Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution. Active site occupation induces large changes in secondary structure content in thrombin as shown by circular dichroism. Thrombin-D-Phe-Pro-Arg-chloromethyl ketone (PPACK) exhibits enhanced equ...
متن کاملStudies on Thrombin-induced Platelet
The importance of morphologic alteration, clumping, and subsequent fusion of blood platelets in hemostasis and thrombosis is well known. The mechanisms underlying these platelet changes, often referred to as agglutination and viscous metamorphosis, are poorly understood. Since the early work of Wright and Minot (1), many studies have suggested that thrombin may be involved. Widely divergent con...
متن کاملStructural studies on human type IV collagen.
Type IV collagen was isolated from limited pepsin digests of human placenta by selective salt precipitation at acidic and neutral pH. The native protein was resistant to human skin collagenase but was cleaved by a rat mast cell protease. Molecular sieve chromatography of the reduced and alkylated material separated relatively homogeneous components of molecular weight 140,000 (140K) and 100,000...
متن کاملStructural flexibility of human α‐dystroglycan
Dystroglycan (DG), composed of α and β subunits, belongs to the dystrophin-associated glycoprotein complex. α-DG is an extracellular matrix protein that undergoes a complex post-translational glycosylation process. The bifunctional glycosyltransferase like-acetylglucosaminyltransferase (LARGE) plays a crucial role in the maturation of α-DG, enabling its binding to laminin. We have already struc...
متن کاملStudies on Thrombin-induced Platelet Agglutination
A one-stage macroscopic test for platelet agglutination was used to study the effect of thrombin and thrombin-cation mixtures on washed platelets. Conclusions regarding platelet agglutination are as follows: (a) Canine, bovine, or human thrombin alone does not cause agglutination of canine or human platelets. (b) Thrombin with calcium or magnesium causes rapid platelet agglutination. Both calci...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2005
ISSN: 0108-7673
DOI: 10.1107/s0108767305089609