Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains
نویسندگان
چکیده
منابع مشابه
Expression and Evaluation of HuscFv Antibody -PE40 Immunotoxin for Target Therapy of EGFR-Overexpressing Cancers
Background: Epidermal growth factor receptor (EGFR) plays an important role in the progression and tumorigenesis of the various cancers. In this regards, anti-EGFR antibodies are valuable approved therapeutics for the EGFR over-expressing cancers. However, the occurrence of mutations in the EGFR and/or KRAS genes; a common phenomenon which is seen in many cancers, lead to the r...
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To better understand how the relatively flat antigen-combining sites of antibodies interact with the concave shaped substrate-binding clefts of proteases, we determined the structures of two antibodies in complex with the trypsin-like hepatocyte growth-factor activator (HGFA). The two inhibitory antibodies, Ab58 and Ab75, were generated from a human Fab phage display library with synthetic dive...
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We present a formal solution to the problem of situation identification in learning of structural concepts. Structural concepts are characterized by the interrelationships and attributes of their parts, rather than by just their own direct attributes. Our solution extends the declarative approach to bias of (Russell and Grosof, 1987) by formalizing the beliefs about relevancy in a more complex ...
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ژورنال
عنوان ژورنال: Structure
سال: 2013
ISSN: 0969-2126
DOI: 10.1016/j.str.2013.05.008