Structural determinants regulating cell surface targeting of melanocortin receptors
نویسندگان
چکیده
منابع مشابه
Molecular evolution of GPCRs: Melanocortin/melanocortin receptors.
The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are activated by melanocortin ligands derived from the proprotein, proopiomelanocortin (POMC). During the radiation of the gnathostomes, the five receptors have become functionally segregated (i.e. melanocortin 1 receptor (MC1R), pigmentation regulation; MC2R, glucocorticoid synthesis; MC3R and MC4R, energy homeo...
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Adrenocorticotropic hormone and alpha-, beta-, and gamma-melanocyte-stimulating hormones, collectively called melanocortin peptides, exert multiple effects upon the host. These effects range from modulation of fever and inflammation to control of food intake, autonomic functions, and exocrine secretions. Recognition and cloning of five melanocortin receptors (MCRs) has greatly improved understa...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2013
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-13-0055