Structural Determinants of Water Permeability through the Lipid Membrane
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Structural Determinants of Water Permeability through the Lipid Membrane
Despite intense study over many years, the mechanisms by which water and small nonelectrolytes cross lipid bilayers remain unclear. While prior studies of permeability through membranes have focused on solute characteristics, such as size, polarity, and partition coefficient in hydrophobic solvent, we focus here on water permeability in seven single component bilayers composed of different lipi...
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Dear Sir: In a recent article, Finkelstein (1976) has shown that the measured water permeabil i ty th rough a leci thin-decane planar bilayer m em b ran e is similar to the calculated permeabili ty t h rou g h a sheet o f n h e x a d e c a n e 50 ,~ thick. Th a t is, the measured water permeabil i ty, Pa, was found equal to DKhc/AX, where D is the diffusion constant o f water in water, Khe is t...
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Naturally occurring pores show a variety of polarities and sizes that are presumably directly linked to their biological function. Many biological channels are selective toward permeants similar or smaller in size than water molecules, and therefore their pores operate in the regime of single-file water pores. Intrinsic factors affecting water permeability through such pores include the channel...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2007
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200709848