Structural Determinants of Unique Properties of Human IgG4-Fc
نویسندگان
چکیده
منابع مشابه
Structural Determinants of Unique Properties of Human IgG4-Fc☆
Human IgG4, normally the least abundant of the four subclasses of IgG in serum, displays a number of unique biological properties. It can undergo heavy-chain exchange, also known as Fab-arm exchange, leading to the formation of monovalent but bispecific antibodies, and it interacts poorly with FcγRII and FcγRIII, and complement. These properties render IgG4 relatively "non-inflammatory" and hav...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2014
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2013.10.039