Structural Determinants of Integrin Recognition by Talin
نویسندگان
چکیده
منابع مشابه
Structural Determinants of Integrin Binding to the Talin Rod*S⃞
The adaptor protein talin serves both to activate the integrin family of cell adhesion molecules and to couple integrins to the actin cytoskeleton. Integrin activation has been shown to involve binding of the talin FERM domain to membrane proximal sequences in the cytoplasmic domain of the integrin beta-subunit. However, a second integrin-binding site (IBS2) has been identified near the C-termi...
متن کاملStructural Basis of Integrin Activation by Talin
Regulation of integrin affinity (activation) is essential for metazoan development and for many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to integrin beta subunit cytoplasmic domains (tails) causes activation, whereas numerous other PTB-domain-containing proteins bind integrins without activating them. Here we define the structure of a complex between tal...
متن کاملStructural diversity in integrin/talin interactions.
The adhesion of integrins to the extracellular matrix is regulated by binding of the cytoskeletal protein talin to the cytoplasmic tail of the β-integrin subunit. Structural studies of this interaction have hitherto largely focused on the β3-integrin, one member of the large and diverse integrin family. Here, we employ NMR to probe interactions and dynamics, revealing marked structural diversit...
متن کاملTalin controls integrin activation.
Tight, dynamic control of the affinity of integrin adhesion receptors for their extracellular ligands (integrin activation) is essential for the development and functioning of multicellular organisms. Integrin activation is controlled by intracellular signals that, through their action on integrin cytoplasmic domains, induce conformational changes in integrin extracellular domains, resulting in...
متن کاملStructural Basis of Collagen Recognition by Integrin α2β1
and ␣X) contain an additional domain (" A " or " I ") that is inserted into the head region, where it plays a central role in ligand binding: thus, recombinant I domains reca-pitulate many of the ligand-binding properties of the The first crystal struc-United Kingdom † Department of Biochemistry ture of an I domain showed that it adopts the " dinucleo-tide-binding " fold, with a central mostly ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2003
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(02)00823-7