Structural determinants of cooperativity in acto-myosin interactions.
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چکیده
منابع مشابه
Structural determinants of cooperativity in acto-myosin interactions.
Regulation of muscle contraction is a very cooperative process. The presence of tropomyosin on the thin filament is both necessary and sufficient for cooperativity to occur. Data recently obtained with various tropomyosin isoforms and mutants help us to understand better the structural requirements in the thin filament for cooperative protein interactions. Forming an end-to-end overlap between ...
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Mechanochemical interactions between myosin and actin-troponin-tropomyosin (regulated thin filaments) underlie muscle contraction. Generally, the binding of a myosin molecule to a regulated thin filament facilitates the binding of nearby myosin; binding is cooperative. A simple yet accurate theoretical description of this cooperativity is lacking. From a general mechanochemical model that treat...
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It is well known that many biochemical processes in the cell such as gene regulation, growth signals and activation of ion channels, rely on mechanical stimuli. However, the mechanism by which mechanical signals propagate through cells is not as well understood. In this review we focus on stress propagation in a minimal model for cell elasticity, actomyosin networks, which are comprised of a su...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 2002
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.2002_3740