Structural Determinants of Allosteric Ligand Activation in RXR Heterodimers
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چکیده
منابع مشابه
Structural Determinants of Allosteric Ligand Activation in RXR Heterodimers
Allosteric communication underlies ligand-dependent transcriptional responses mediated by nuclear receptors. While studies have elucidated many of the components involved in this process, the energetic architecture within the receptor protein that mediates allostery remains unknown. Using a sequence-based method designed to detect coevolution of amino acids in a protein, termed the statistical ...
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ژورنال
عنوان ژورنال: Cell
سال: 2004
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(04)00119-9