منابع مشابه
Structural biology of innate immunity.
Innate immune responses depend on timely recognition of pathogenic or danger signals by multiple cell surface or cytoplasmic receptors and transmission of signals for proper counteractions through adaptor and effector molecules. At the forefront of innate immunity are four major signaling pathways, including those elicited by Toll-like receptors, RIG-I-like receptors, inflammasomes, or cGAS, ea...
متن کاملSystems biology of innate immunity.
Systems Biology has emerged as an exciting research approach in molecular biology and functional genomics that involves a systematic use of genomic, proteomic, and metabolomic technologies for the construction of network-based models of biological processes. These endeavors, collectively referred to as systems biology establish a paradigm by which to systematically interrogate, model, and itera...
متن کاملSystems biology and innate immunity.
use of systems biology approaches to better understand innate immunity. Inflammatory disorders or syndromes are readily amenable to investigation by systems biology approaches, largely because an extensive repertoire of antibodies, reagents and assays exists for the evaluation of inflammatory cells and molecules. Moreover, inflammatory disorders often have systemic sequelae such as changes in a...
متن کاملInnate immunity
From the discovery of antibodies in the late nineteenth century until very recently, the focus of most research in immunology has been the so-called adaptive immune response. Adaptive immune responses are highly specific for a given microorganism and it is the T and B lymphocytes of the adaptive immune response, and the antibodies produced by the B lymphocytes, that are responsible for lasting ...
متن کاملInnate immunity.
Recent years have witnessed an explosion of interest in the innate immune system. Questions about how the innate immune system senses infection and empowers a protective immune response are being answered at the molecular level. These basic science discoveries are being translated into a more complete understanding of the central role innate immunity plays in the pathogenesis of many human infe...
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ژورنال
عنوان ژورنال: Annual Review of Immunology
سال: 2015
ISSN: 0732-0582,1545-3278
DOI: 10.1146/annurev-immunol-032414-112258