Structural Biology and Protein Engineering of Thrombolytics

architecture and engineering of nanoscale sculptured thin films and determination of their properties

چکیده ندارد.

Structural Bioinformatics for Protein Engineering

Structural biology of G protein-coupled receptors.

More than 60% of the current drugs are based on G protein-coupled receptors. Paradoxically, high-resolution structures are not available to facilitate rational drug design. Difficulties in expression, purification, and crystallization of these transmembrane receptors are the reasons for the low success rate. Recent individual and network-based technology development has significantly improved o...

Structural biology of the PCI-protein fold

The PCI fold is based on a stack of α-helices topped with a winged-helix domain and is found in a range of proteins that form central parts of large complexes such as the proteasome lid, the COP9 signalosome, elongation factor eIF3, and the TREX-2 complex. Recent structural determinations have given intriguing insight into how these folds function both to facilitate the generation of larger pro...

Bridging structural biology and genomics: assessing protein– protein interaction datasets

Currently, there is a major effort to map protein–protein interactions on a genome-wide scale. The utility of the resulting interaction networks will depend on the reliability of the experimental methods and the coverage of the approaches. Known macromolecular complexes provide a defined and objective set of protein interactions with which to compare biochemical and genetic data for validation....