Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP)
نویسندگان
چکیده
منابع مشابه
Quantification of human plasma phospholipid transfer protein (PLTP): relationship between PLTP mass and phospholipid transfer activity.
A sensitive sandwich-type enzyme-linked immunosorbent assay (ELISA) for human plasma phospholipid transfer protein (PLTP) has been developed using a monoclonal capture antibody and a polyclonal detection antibody. The ELISA allows for the accurate quantification of PLTP in the range of 25-250 ng PLTP/assay. Using the ELISA, the mean plasma PLTP concentration in a Finnish population sample (n = ...
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It has been reported that phospholipid transfer protein (PLTP) is an independent risk factor for human coronary artery disease. In mouse models, it has been demonstrated that PLTP overexpression induces atherosclerosis, while its deficiency reduces it. PLTP is considered a promising target for pharmacological intervention to treat atherosclerosis. However, we must still answer a number of quest...
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Source and Description of Primers. Primers for the Phospholipid Transfer Protein gene (PLTP) were designed from homologous regions of published human and mouse PLTP sequences (GenBank accession number NM_006227 and NM_011125, respectively). The primers were used to amplify a 1,368-bp fragment of the porcine PLTP gene spanning an intron between exons 4 and 5. Porcine PLTP sequences were sequence...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
سال: 2018
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2018.06.001