Structural basis for promiscuous action of monoterpenes on TRP channels
نویسندگان
چکیده
منابع مشابه
TRP channels entering the structural era.
Transient receptor potential (TRP) channels are important in many neuronal and non-neuronal physiological processes. The past 2 years have seen much progress in the use of structural biology techniques to elucidate molecular mechanisms of TRP channel gating and regulation. Two approaches have proven fruitful: (i) a divide-and-conquer strategy has provided high-resolution structural details of T...
متن کاملTRP channels.
The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that it displays greater diversity in activation mechanisms and selectivities than any other group of ion channels. The domain organizations of some TRP proteins are also unusual, as they consist of linked channel and enzyme domains. A unifying theme in this group is that TRP proteins play critical roles in s...
متن کاملPharmacology of TRP Channels
TRP channels are a family of ion channels involved in a plethora of physiological sensory processes. Since their discovery they have attracted the attention of academic and non-academic laboratories with the aim of developing modulators that could be used as pharmacological tools for unveiling their physiological and pathological activities, and as therapeutic compounds for intervening in TRP d...
متن کاملNeurobiology of TRP Channels
The field studying transient receptor potential (TRP) channels, while less than fifty years old, has grown precipitously in the past few decades, revealing roles for these channels across multiple organ systems and sensory modalities. Editor Tamara Luti Rosenbaum Emir, along with a multitude of authors who are experts in their fields, truly capture the scope and complexity of these channels in ...
متن کاملTRP channels and thermosensation.
Recent years have seen great advances in the molecular description of sensory neurobiology. Of the five popularly characterized senses (sight, hearing, taste, smell and touch), touch is perhaps the most varied and least understood. Within this modality is the ability to sense mechanical forces, chemical stimuli, and temperature, and the molecules that mediate this ability have been a long-stand...
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ژورنال
عنوان ژورنال: Communications Biology
سال: 2021
ISSN: 2399-3642
DOI: 10.1038/s42003-021-01776-0