منابع مشابه
Structural basis for DNA 5´-end resection by RecJ
The resection of DNA strand with a 5´ end at double-strand breaks is an essential step in recombinational DNA repair. RecJ, a member of DHH family proteins, is the only 5´ nuclease involved in the RecF recombination pathway. Here, we report the crystal structures of Deinococcus radiodurans RecJ in complex with deoxythymidine monophosphate (dTMP), ssDNA, the C-terminal region of single-stranded ...
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STAT6 participates in classical IL-4/IL-13 signaling and stimulator of interferon genes-mediated antiviral innate immune responses. Aberrations in STAT6-mediated signaling are linked to development of asthma and diseases of the immune system. In addition, STAT6 remains constitutively active in multiple types of cancer. Therefore, targeting STAT6 is an attractive proposition for treating related...
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The homohexameric (L)Sm protein Hfq is a central mediator of small RNA-based gene regulation in bacteria. Hfq recognizes small regulatory RNAs (sRNAs) specifically, despite their structural diversity. This specificity could not be explained by previously described RNA-binding modes of Hfq. Here we present a distinct and preferred mode of Hfq-RNA interaction that involves the direct recognition ...
متن کاملStructural Basis for Cooperative DNA
when the bacterial environment contains no lactose (Al-berts et al., 2002; Berg et al., 2002). The repressor functions as a dimer of two " hand " domains (Figure 1D). loop is critical for the lac operon repression (Matthews, 1992). The primary roles of CAP and LR are the opposite of Summary each other, yet the two proteins bind to DNA cooperatively (Hudson and Fried, 1990; Lewis et al., 1996). ...
متن کاملStructural Basis of hAT Transposon End Recognition by Hermes, an Octameric DNA Transposase from Musca domestica
Hermes is a member of the hAT transposon superfamily that has active representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species. The crystal structure of the Hermes transposase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers. Although isolated dimers are active in vitro for all the chemical steps of transpos...
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ژورنال
عنوان ژورنال: eLife
سال: 2016
ISSN: 2050-084X
DOI: 10.7554/elife.14294