Structural Basis for Depletion of Heat Shock Protein 90 Client Proteins by Deguelin
نویسندگان
چکیده
منابع مشابه
Structural basis for depletion of heat shock protein 90 client proteins by deguelin.
BACKGROUND The molecular chaperone heat shock protein 90 (Hsp90) participates in preserving the expression and activity of various oncoproteins, including hypoxia-inducible factor 1alpha (HIF-1alpha) and Akt. Deguelin is a rotenoid with antitumor activities. We investigated whether the antitumor activities of deguelin involve the functional inhibition of Hsp90. METHOD Human xenograft tumors w...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2007
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djm007