Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1
نویسندگان
چکیده
منابع مشابه
Structural and functional characterization of the phosphorylation-dependent interaction between PML and SUMO1.
PML and several other proteins localizing in PML-nuclear bodies (PML-NB) contain phosphoSIMs (SUMO-interacting motifs), and phosphorylation of this motif plays a key role in their interaction with SUMO family proteins. We examined the role that phosphorylation plays in the binding of the phosphoSIMs of PML and Daxx to SUMO1 at the atomic level. The crystal structures of SUMO1 bound to unphospho...
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ژورنال
عنوان ژورنال: Structure
سال: 2015
ISSN: 0969-2126
DOI: 10.1016/j.str.2014.10.015