Structural Analysis of p28 Adult T-Cell Leukaemia-associated Antigen
نویسندگان
چکیده
منابع مشابه
A case report of adult T-cell leukaemia/lymphoma (ATLL).
Adult T-cell leukaemia/lymphoma (ATLL) is a unique disease with distinct manifestations, a characteristic phenotype and a likely retroviral aetiology. It is unusual in Southeast Asia, though more commonly seen in some countries like Japan. We report a case of this disease in a 71-year-old man in Singapore who presented with papular erythematous eruptions for 6 years and subsequently developed g...
متن کاملA case report of adult T-cell leukaemia/lymphoma.
Adult T-cell leukaemia/lymphoma (ATLL) is a rare T lymphoproliferative disorder which is aetiologically linked with human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 is endemic in Japan, Caribbean and Africa. The highest incidence of ATLL is in Japan although sporadic cases have been reported elsewhere in the world. We describe a case of ATLL with an unusual presentation which we believe ...
متن کاملClinical Trials of Adult T-Cell Leukaemia/Lymphoma Treatment
Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive malignancy of mature activated T cells caused by human T-cell lymphotropic virus type I (HTLV-1). Prognosis is severe because of intrinsic chemoresistance and severe immuosuppression. Four different subtypes are described with different outcomes, and treatment strategies vary according to the different clinical courses. Japanese trials sho...
متن کاملP28. Efficient CD19-positive leukaemia cell lysis mediated by a T cell-recruiting triple body a[19-3-19]
Background The design of antibody derivatives with higher tumour cell selectivity is hoped to improve cancer immunotherapy and to decrease side effects. One promising molecular format that we have developed is the triple body. A triple body allows for selective lysis based on its ‘dual targeting’ capacity. The triple body format consists of three linked single chain variable fragments (scFv) wi...
متن کاملAdult T-cell leukaemia/lymphoma (ATLL) and T-cell leukemia virus type 1 (HTLV1)
Epidemiology The disease has a long latency, and affected individuals usually are exposed to the virus very early in life. The virus may be transmitted in breast milk, and through exposure to blood and blood products. The cumulative incidence of ATLL is estimated to be 2.5% among HTLV-1 carriers in Japan (1). Sporadic cases have been found in the United State and elsewhere. It occurs in adults ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1986
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-67-7-1373