Stromal p16 expression is significantly increased in endometrial carcinoma

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Stromal p16 expression is significantly increased in endometrial carcinoma

p16 is a negative regulator of cell proliferation and is considered a tumor suppressor protein. Alterations in p16 protein expression are associated with tumor development and progression. However, the p16 expression status in the peritumoral stroma has not been investigated in the endometrium. Therefore, we evaluated stromal p16 expression in different types of endometrial lesions using immuno...

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BACKGROUND Importin13 (IPO13) is a novel potential marker of corneal epithelial progenitor cells. We investigated the expression and localization of IPO13 in endometrial, endometriotic and endometrial carcinoma tissue. MATERIAL/METHODS IPO13 expression in endometrial, endometriotic and endometrial carcinoma tissue was examined by immunohistochemistry, qPCR and Western blot. RESULTS Immunohi...

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Decidualisation of human endometrial stromal cells is associated with increased expression and secretion of prorenin

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Endometrial Stromal Nodule

The endometrial stromal nodule is a benign tumor composed of differentiated endometrial stromal cells arranged as a well circumscribed nodule with smooth non-invasive margins. They are rare neoplasms, diagnosed in most instances by microscopy. Although nodules are benign in nature, hysterectomy is the treatment of choice to enable evaluation of the tumor margins which are well demarcated in...

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ژورنال

عنوان ژورنال: Oncotarget

سال: 2016

ISSN: 1949-2553

DOI: 10.18632/oncotarget.13594