Stromal and intraepithelial tumor‑infiltrating lymphocytes in colorectal carcinoma

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Stromal and intraepithelial tumor-infiltrating lymphocytes in colorectal carcinoma

The local mechanisms of antitumor immune defense determine the development and organization of the tumor microenvironment, and the composition and relative proportions of the inflammatory cell population affect the quality and characteristics of the immune response. The aim of the present study was to conduct a quantitative morphological evaluation of two types of tumor-infiltrating lymphocyte ...

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Differing phenotypes between intraepithelial and stromal lymphocytes in early-stage tongue cancer.

The significance of tumor-infiltrating lymphocytes (TIL) has attracted much attention in relation to the prognosis of patients. We herein examined the activation status of the TILs in relation to the tumor microenvironment. By using frozen sections of human early-stage tongue cancers (n = 22), the TILs in the cancer nests and those in the cancer stroma were compared for the expression of PD-1, ...

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The epithelial surface is the site at which we first encounter pathogens. Two recent advances indicate that intraepithelial lymphocytes use specialized tools to help protect this surface.

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Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients

Background: Increased number of intestinal intraepithelial lymphocytes (IELs) is a key histological finding in the diagnosis of celiac disease (CD); however, the number of IELs in celiac patients and healthy subjects may vary from one region to another. Additionally, there are some seronegative celiac patients with a borderline histology. Objective: To determin...

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Quantitation of intraepithelial lymphocytes in human jejunum.

An estimate of the number of intraepithelial lymphocytes in jejunal villous epithelium can be obtained by differential counting of nuclei in the epithelium. From counts carried out in 160 jejunal biopsies from patients who did not have coeliac disease the normal range has been established as 6-40 intraepithelial lymphocytes per 100 villous epithelial cells. In some biopsies there was a moderate...

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ژورنال

عنوان ژورنال: Oncology Letters

سال: 2017

ISSN: 1792-1074,1792-1082

DOI: 10.3892/ol.2017.7013