Stroke-Induced Central Pain: Overview of the Mechanisms, Management, and Emerging Targets of Central Post-Stroke Pain

The incidence of stroke plays the foremost role in genesis central neuropathic pain. Central post-stroke pain (CPSP) is a arising from vascular lesion nervous system that elicits somatosensory deficits, often contralateral to lesions. It expressed as continuous or intermittent accompanied by sensory abnormalities like dysesthesia and allodynia. CPSP remains de-emphasized due variation onset diversity symptoms, besides difficulty distinguishing it other pains, referred diagnosis exclusion. Spinothalamic dysfunction, disinhibition medial thalamus, neuronal hyperexcitability combined with deafferentation thalamocortical regions are mechanisms underlying pain, which play significant pathogenesis CPSP. treatment regimen for seems be perplexed nature; however, based on available studies, amitriptyline lamotrigine denoted first-line medications non-pharmacological choices may accounted cases intractable pharmacotherapy. This review attempts provide an overview mechanisms, existing management approaches, emerging targets A profound understanding aids optimizing quality life among sufferers facilitates further research develop newer therapeutic agents managing