Stressful life events and catechol-O-methyl-transferase (COMT ) gene in bipolar disorder
نویسندگان
چکیده
منابع مشابه
Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders.
It is well established that stress is a risk factor for onset of mood disorders. Emerging evidence suggests that genetic vulnerability may also moderate individual responsiveness to stress. The most compelling evidence regards the polymorphism within the promoter region of the serotonin transporter gene (SERTPR), which has been reported to moderate the risk for depression, in conjunction with l...
متن کاملCatechol-O-methyl transferase and schizophrenia.
Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Gi...
متن کاملAssociation between Catechol-O-Methyltransferase Gene Variant and Bipolar Disorder
Emotional dysregulation is a core characteristic of many psychiatric diseases. Bipolar disorder is a brain disorder that causes unusual shifts in mood, energy level, activity level and ability to carry day to day work. CatecholO-methyltransferase (COMT) is involved in the metabolism of dopamine and epinephrine. To a large extent it is responsible in maintaining human cognitive functioning. Poly...
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Catechol-O-methyl tranferase (COMT; E.C.2.1.1.6) is widely distributed enzyme in nature that plays an essential role in the metabolism of catechol neurotransmitters and catechol linked foreign entities. As L-DOPA, a key medicine in Parkinsonism is being catabolised by COMT, this justified the interest in developing improved COMT inhibitors as significant adjunct to L-DOPA therapy. Although tolc...
متن کاملassociation of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia
background : a single nucleotide variation within atechol-o-methyl transferase (comt) gene may alter the comt enzyme activity level. polymorphism of val158met in the comt gene has been related to malignancy. in this regard, a study was carried out to find a possible association between the comt gene polymorphism in patients with sporadic prostate cancer (pca) and benign prostatic hyperplasia (...
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ژورنال
عنوان ژورنال: Depression and Anxiety
سال: 2017
ISSN: 1091-4269
DOI: 10.1002/da.22606