Stress-Fibers Dictate Cellular Curvature & Force Exertion
نویسندگان
چکیده
منابع مشابه
The tension mounts: Stress fibers as force-generating mechanotransducers
Stress fibers (SFs) are often the most prominent cytoskeletal structures in cells growing in tissue culture. Composed of actin filaments, myosin II, and many other proteins, SFs are force-generating and tension-bearing structures that respond to the surrounding physical environment. New work is shedding light on the mechanosensitive properties of SFs, including that these structures can respond...
متن کاملModel of cellular mechanotransduction via actin stress fibers.
Mechanical stresses due to blood flow regulate vascular endothelial cell structure and function and play a key role in arterial physiology and pathology. In particular, the development of atherosclerosis has been shown to correlate with regions of disturbed blood flow where endothelial cells are round and have a randomly organized cytoskeleton. Thus, deciphering the relation between the mechani...
متن کاملCurvature force and dark energy
A curvature self-interaction of the cosmic gas is shown to mimic a cosmological constant or other forms of dark energy, such as a rolling tachyon condensate or a Chaplygin gas. Any given Hubble rate and deceleration parameter can be traced back to the action of an effective curvature force on the gas particles. This force self-consistently reacts back on the cosmological dynamics. The links bet...
متن کاملAtomic force microscopy on fibers
Natural and synthetic fibers exhibit a huge diversity regarding their dimension, structure and physical-chemical properties. The wanted properties of textiles are adjusted by directed selection, development and processing of fiber material. Atomic force microscopy offers as sole method the possibility to acquire quantitative information in the nanoand micro range under environmental conditions ...
متن کاملCurvature and Rho activation differentially control the alignment of cells and stress fibers
In vivo, cells respond to a host of physical cues ranging from substrate stiffness to the organization of micro- and nanoscale fibrous networks. We show that macroscale substrates with radii of curvature from tens to hundreds of micrometers influence cell alignment. In a model system of fibroblasts, isolated cells aligned strongly in the axial direction on cylinders with radii similar to the ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.2051