Streptozotocin‐Induced Diabetic Models in Mice and Rats
نویسندگان
چکیده
Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β-cell destruction and widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ-induced insulin deficiency hyperglycemia mice rats. Also described creating animal models 2 using STZ. These animals employed assessing the pathological consequences screening potential therapies treatment condition. © 2021 The Authors.
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ژورنال
عنوان ژورنال: Current protocols
سال: 2021
ISSN: ['2691-1299']
DOI: https://doi.org/10.1002/cpz1.78