Strategies to Augment Natural Killer (NK) Cell Activity against Solid Tumors
نویسندگان
چکیده
منابع مشابه
Cytotoxicity of activated natural killer cells against pediatric solid tumors.
PURPOSE To develop new therapies for children with solid tumors, we tested the cytotoxicity of natural killer (NK) cells expanded by coculture with K562-mb15-41BBL cells. We sought to identify the most sensitive tumor subtypes, clarify the molecular interactions regulating cytotoxicity, and determine NK antitumor potential in vivo. EXPERIMENTAL DESIGN We tested in vitro cytotoxicity of expand...
متن کاملNatural killer cells and solid tumors.
Natural killer (NK) cells play an important role in the innate immune response against cancer, in particular in the elimination of tumor metastases and small tumors. NK cell-mediated control of large solid tumors is usually not efficient, although tumors often express high amounts of activating ligands and low levels of inhibitory ligands, such as MHC class I. Thus, we assume that these tumors ...
متن کاملNatural killer (NK) activity of normal human peripheral blood lymphocytes against erythroleukemic cell line K 562.
Human peripheral blood lymphocytes of healthy donors showed significant levels of natural killer (NK) activity against erythroleukemic cell line K 562 in 3-hour 51Cr release assays. The levels of NK activity showed much individual variation, which was considered to be an individual trait that varied little under physiological conditions. The NK activity of mononuclear leukocytes from cord blood...
متن کاملHyperthermia Increases Natural Killer Cell Cytotoxicity against SW-872 Liposarcoma Cell Line
Background: Although there is convincing data in support of the effectiveness of hyperthermia in tumor therapy, the molecular mechanisms underlying the clinical effects of hyperthermia are still poorly understood. Objective: To investigate natural killer (NK) cell cytotoxicity against heat-treated SW-872 and HeLa tumor cell lines. Methods: NKG2D ligands and HLA class I transcription were examin...
متن کاملEsophageal natural killer (NK)/T cell lymphoma of true natural killer cell origin.
A 53-year-old man with no prior medical history was transferred to our hospital because of a 2-month history of dysphagia with throat pain. A complete blood count showed hemoglobin 14.2g/dL, and white blood cell count 11890/mL, and other laboratory findings were within normal limits. An enhanced computed tomography (CT) scan showed diffuse thickening of the esophageal wall without regional lymp...
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ژورنال
عنوان ژورنال: Cancers
سال: 2019
ISSN: 2072-6694
DOI: 10.3390/cancers11071040