Strategies of mucosal immunotherapy for allergic diseases
نویسندگان
چکیده
منابع مشابه
Immunotherapy - Vaccines for allergic diseases.
Allergic diseases are some of the most commonly encountered problems in clinical practice. Drugs such as corticosteroids and antihistamines can provide effective symptomatic relief, but do not alter the course of the disease. Specific immunotherapy (SIT) was first used to treat pollen allergy in 1911, and has since evolved into an effective treatment for allergic rhinitis and asthma. SIT has be...
متن کاملAllergen immunotherapy (desensitisation) for allergic diseases.
tion) involves the repeated administration of allergen extracts to allergic individuals to induce a state of clinical and immunological tolerance. Traditionally, this has involved repeated subcutaneous injections of incremental doses of allergen over a period of 8–16 weeks followed by monthly ‘maintenance’ injections for 3–5 years. Modified approaches have included shorter and preseasonal regim...
متن کاملOral mucosal immunotherapy for allergic rhinitis: A pilot study.
BACKGROUND The sublingual mucosa has been used for many years to apply allergenic extracts for the purpose of specific immunotherapy (IT). Although sublingual IT (SLIT) is both safe and efficacious, the density of antigen-presenting cells is higher in other regions of the oral cavity and vestibule, which make them a potentially desirable target for IT. OBJECTIVE To present the concept of oral...
متن کاملAntigen-specific immunotherapy of autoimmune and allergic diseases
Nearly a century has passed since the first report describing antigen-specific immunotherapy (antigen-SIT) was published. Research into the use of antigen-SIT in the treatment of both allergic and autoimmune disease has increased dramatically since, although its mechanism of action is only slowly being unravelled. It is clear though, from recent studies, that success of antigen-SIT depends on t...
متن کاملImmunotherapy for allergic rhinitis.
Allergic rhinitis (AR) affects more than 20% of the population in the United Kingdom and western Europe and represents a major cause of morbidity that includes interference with usual daily activities and impairment of sleep quality. This guidance prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI) is for the management of AR in ...
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ژورنال
عنوان ژورنال: Cellular & Molecular Immunology
سال: 2011
ISSN: 1672-7681,2042-0226
DOI: 10.1038/cmi.2011.17